Well, understand that I am mainly talking from my VMI team, but it seems to me that Block at the Power forward and Center, especially when combined with good defensive ratings, has more effect in Zone. The zone I have tried at other levels, I have had some good success with a shot blocking SF though, especially if you are running a two three.
The lineups that seemed(Again, for me) to do best at the three two involved basically a three guard lineup with two strong bigs.