heck, this is what I have done with the rec league kids team that I coach - its not seniors, but when I am able to rotate the 3 or 4 of the stronger players onto the floor together we run a 1-2-2 press - at full or 3/4 court and then fall back into a zone - when we have too many of the weaker kids on the floor we pull back and just run the zone
I like the idea for HD because it would create interesting dynamic of depth chart and game plan working together
on the other hand, it seems hard to define when the different game plans would go active - it would be complex unless you just said something very clear like "when starting lineup is in the game" or something....