This seems to hold true the vast majority of the time:
Long Relief A/B - Long relief pitchers are the first to come in when the starting pitcher is removed early (generally before the 7th) in a game that is still in doubt. These are usually relief pitchers who are capable of pitching multiple innings of relief at maximum effectiveness. Unless settings in the Edit Players Settings page dictate otherwise, the long relief A pitcher will be given first priority to enter a game when this situation arises and the score is still close. If there is a wide margin in the score your long relief B pitcher will have a better chance of appearing in the game. If a long relief pitcher must leave the game during what is still a long relief situation, first replacement priority will be given to another long relief pitcher. For reference, these are also often times spot starters for teams in case of injury.