Here's some pretty basic stuff that I do: (1) Determine if the other team is, on average, better or worse than yours. If considerably better, run slowdown, if considerably worse, run uptempo (if you have decent depth). (2) Check to see if the other team is an "inside" or "outside" team, based on LP and PER ratings and on # of 3pt attempts/game. Adjust team defense setting based on that. (3) If opponent plays mtm, see which starters are weak defenders and which are strong and adjust distro slightly based on that. (4) If opponents plays fcp, get better passers more playing time (as long as they're relatively comparable players) by adjusting fatigue settings. Just a few things you can try.