If the other team has 3+ walkons, uptempo. Always.
If my speed and athleticism are both higher than my opponent's, uptempo (my belief is these two cats are weighted heavily by the engine...if I have the edge in both, I want as many possessions as possible for that bias to come through).
If my opponent is weak on the bench (lots of freshmen, for instance), uptempo (I want to force those kids on the court and try to take advantage.)