The average pitches per 9 innings in this league is 178. That's 28894 pitches required for 162 9 inning games. To get that many pitches, you need to draft 1913 innings (at 15.1 pitches per real-life inning pitched).
This "average" is skewed because several owners are allowing pitchers to pitch when very fatigued. There are 8 owners averaging less than 172 pitches per game. That equates to roughly 1848 real life innings.
Every pitcher starts the season with a certain number of pitches "in the bank". As the season wears on, his pitch balance decreases. Pitching at anything less than 100% causes the balance to decrease more quickly because he allows more hits and throws more balls. This has a snow balling effect. The more fatigued a pitcher is, the more pitches he uses up per inning causing him to fatigue even faster. I try to absolutely never use a pitcher when he is not at least 99%. I also try to maximize the pitches my starters use by calculating his per-game allotment and setting his target to that number and his pull setting to "1". My goal is to finish the season with my very best pitchers 100% used up (well actually 95% if I'm heading into the playoffs).
This particular league is a bit unusual in that Pedro, Maddux, W. Johnson, Mathewson, Joss, Alexander, Chamberlain, Gagne, and Eckersley are blacklisted. So we got lots of Browns, Walshes and King Silver's.
King Silver presents a unique problem regarding drafting innings pitched in that you have to get 127 pitches out of him every other game in order to maximize his innings. Not realistic. Best I've seen anyone do is about 83%, so you can throw 120 of his 703 innings out the window, making his "real-life" innings pitched more like 583.
That being said, I drafted Silver, Walsh and Brown for my starters and 9 of the best relievers (imho) for a total of 1815 real life innings. With lots of $$$ left, I filled my last pitcher spot with Koufax to be my mop-up/saftey cushion. Turns out he is doing as well as Brown or Silver, so I'm using him a bit more than I anticipated.
Bottom line - 58 games into the season, I'm on a pace to use 1848 real life innings-pitches. I'm in line for the wild card as I'm in the same division with PennQuaker and his King Silver has an ERA a full 2 runs per game better than mine. Incidently, PQ's team is on a pace to use 1702 real life innings-pitched.