Respectfully speaking, I think it all depends on the particular owner's strategy. Picture a jockey in a horserace where his horse is the favorite, or one of the favorites. He doesn't always go for the early lead and try to stay there from start to finish, because a lot of times, he'll burn the hourse out and will have nothing left for the stretch run. Instead, he'll hang back and stay within striking distance and see how things develop during the course of the race. And as the race gets closer and closer to the end, you'll see him make his move.
That's the approach that I take in leagues that I join. Aside from throwing the first 2-3 games to take a little sting out of the early season dampening factor, I tend to hang back a little by using my backups and AAA guys a lot at the beginning, which means that my teams are often middle of the pack types until about the 30th game or so when I start playing my regulars everyday. This way, at the end of the season when potential playoff teams are running out lineups where everybody is in the low 90s or less, my guys are at 100% which allows me to push them if need be, and I'd want guys like Milacki and McDowell at full strength (and preferably underused) down the stretch.
But again, I think it varies depending on the owner's strategy and how he (or her) goes about the regular season. But me, personally, I manage my teams with an eye to the postseason and having my bread and butter guys at 100% when the that time comes.