I am wondering how everyone sets up their starting staff with regard to 1 thru 5 " how quick to hook". I typically put starters at 4, but sometimes they are still in the game after giving up 4 runs in two innings. I play in high cap leagues, so I am not concerned about innings pitched etc. I set my long relievers at "any" for available innings. Not a math person, but it seems there isn't a formula used to pull pitchers at the correct moment or assure use of the lefty righty match-up possibilities. Ideas?

Just like Bob Melvin............

I use

2 for SP unless it is a pivotal game, then I shorten the leash.
3 for most RP.
1 for Mop.

LH/RH specialists will not normally enter prior to 6th inning, so designate a Long reliever.

Sparky usually calls on lowest OAV pitcher available.

I draft SP heavy, light bullpens. My settings keep SP in most games to eat their innings, prevent bullpen burnout. SP are generally more reliable than RP. My 2 cents.
*Your results may vary...