I set my spring training lineups to switch out the starters after three or four innings. Major leaguers start the first three games, then sit till the last two. Major league starters get one rotation the first five games, then one rotation the final five games. In between everything else is minor leaguers.
Major leaguers end up with about ten at-bats, pitchers two or three appearances (relievers).
It's been suggested that if you completely rest the major leaguers they'll experience a slight decline, but I haven't tested it.