Playing uptempo with only 10 guys might tire them out a bit, but ultimately it depends on who your opponent is for each particular game. If you're playing against a team with a couple walk-ons, uptempo might be a good idea. Personally, however, I would stick to a normal tempo most games. You've got a pretty tough-looking schedule, you might be shooting yourself in the foot playing uptempo instead of normal.
As for fatigue settings, that's a tougher question. An argument could be made for setting everyone to fairly fresh, or setting everyone to getting tired. I would think you should set everyone to fairly fresh; keep rotating guys in and out of the game. Perhaps against a truly inferior team, set your players to getting tired. Honestly, if I were coaching your team, I'd go with target minutes rather than fatigue, and set almost everyone to 19-23. But I'm not the coach and I'm certainly not as accomplished as you are.
I like Mak as your starting PG, I think he'll still grab some rebounds anyways. He's got the highest passing and speed ratings on your team, he's got good BH, good ATH which will only get better.
I like Peterson as the backup PG. He's still a very good player, better than Mak in BH and basically equivalent in passing. Still, Mak has superior ATH, speed and DEF.
Frady seems to be the obvious choice for starting at SG.
I would have Small coming off the bench as backup SG. He can come in and hit some 3s.
I would start Cale at SF. The SF spot would seem to be your trouble area; you can go big or go small here. Regarding fatigue settings, Cale might be the one guy you keep at getting tired no matter what - not because he has superior stamina, but because right now there is no obvious choice to back him up at SF, or at least, no perfect choice.
Bacon, well, he seems to be the odd man out currently. He seems to be more suited to playing SG, 3rd string. However, if Bacon truly has high potential in rebounding, defense, shotblocking and speed, he might be a better fit to play backup SF behind Cale. Bacon's ATH might be his one limitation in terms of playing SF, but your options are limited and as far as backups and starters, I feel your other players are best served elsewhere.
Goligoski would be my pick as starting PF, and clearly he's yours too.
I like Klapper as backup PF. You might want to plug Klapper in as backup SF, too, as opposed to Bacon; but then if Goligoski and Cale are both on the bench, well... Klapper can't be two places at once. I think Klapper is best utilized at PF.
Haggerty as starting C, of course.
Larson as backup C.
It's a very good team you've got. Certainly, depth could be an issue, but it doesn't have to be. I would play normal tempo, fatigue settings at fairly fresh for everyone except Cale. All 10 players are good. Bacon might be the weakest of the bunch, but even then, I suspect you'll need him quite a bit this season, and high potentials in speed, defense, rebounding, and other areas will IMO override the low ATH; Bacon could be a huge key to your team's success this season, and I like him at backup SF behind Cale. Other than the SF position, I think you have pretty obvious choices as far as who will start and who will play backup at PG, SG, PF and C.
Surely, some will disagree with me, and I hope they do, because the more opinions you have about this, the better.