I'm going to give you 3 points of general advice...with the caveat that others may disagree:
-- I prefer to have my players fully rested going into the playoffs, rather than to play for top seed or home field advantage, in most cases.
-- I want the vast majority of of my postseason innings to be thrown by my best pitchers, and I adjust my pitching staff and my settings accordingly
-- In the postseason I micromanage everything on a game by game basis (lineups,pitch counts, general and individual player settings) based on each game's matchups, opponent tendencies, etc. I do not do this in the regular season.