You can do it with other sets too, but you need lots of possessions, so if you’re playing humans, and you have the type of team where they’re slowing it down consistently, it’s going to hurt you. I don’t know exactly where the cutoff is, but I’ve gotten to it (VH) for a full season one time for a non-FB team. It was a flex team where I was running uptempo almost every game, with most distribution going to the guards, FWIW. It doesn’t directly matter, but we were scoring pretty close to 100 ppg, IIRC.