As with all other choices in this game I can think of, the choice to go uptempo is neither inherently good nor bad. It’s a gameplay decision that can work out well in some situations, and poorly in others. So it’s important to understand what it does and doesn’t do.
It doesn’t directly affect the other team’s fatigue. As TJ noted, you can indirectly do this if you can get guys in foul trouble, triggering the fatigue cascade; but if you don’t have an athleticism advantage, or if your opponents defense is excellent (especially if zone), it generally doesn’t work out this way. Nor does it seem to decrease the importance of passing, though that would make some intuitive sense. Faster shots don’t equate to fewer passes in this game, from what I can tell.
Uptempo does increase possessions, so if you have the better team, it is a way to mitigate the risk of an opponent going on a lucky streak and stealing a game. But it also increases your risk for turnover, so if you don’t have good IQ, speed, and ball-handling, it can backfire. It also directly increases your teams fatigue, so if you don’t have good stamina, it can backfire.
There were years at Abilene Christian where I would go uptempo virtually every game. Those were my best years. But my team wasn’t good because I ran uptempo, I ran uptempo because my team was very good, and well suited to it.