When using formations in a playbook your thought process should be about getting the ball to your most rested playmaker who has the highest chance of being defended by one of your opponent's weakest defenders. In other words, it is all about creating the highest percentage of mismatch possibilities during a game either due to reduced ratings of a tired defender or due to pitting your best offensive player against your opponent's worst defensive player. Since this varies wildly between defenses and how your opponent has configured his chosen defense it will all come down to experience, you have to be able to break down your opponent's actual defensive strategy and be able to adjust your formations and playbooks to take the greatest advantage possible of what he is giving you, just like in real-life football.
Because of my experience and the fact that I have intensely experimented with my chosen offense (Trips) against every defense using DII teams in multiple worlds, I have found certain plays that work all of the time. So at a great cost of time and money, I can now use a handful of Trips formations and a couple of playbooks that will always work against any defense, unless of course, I'm facing a significantly superior team. The key to being able to do this is to find out what worked and what didn't work during a game by breaking down those game results in Yatzr's game analyzer and trying to figure out why one formation worked and why another failed.
There are way too many factors that go into a play for me to be able to tell you how to do this, but the key points are to:
* Know your own player's attributes and be able to count the # of failed plays that were due to poor execution
* Who made the play on defense and at what level 1st, 2nd, or 3rd? (Look for things like LB against WR or 3rd level against RB)
* Which of the players was more fatigued offense or defense? (a fatigued player's attributes are diminished)
* How many progressions did your QB go through during the play and was he under duress? (The # of progressions that you can allow without incurring sacks, interceptions, bad throws, or balls thrown away is based on the skill level of your team)
* Time of possession (Just like in real life, your offense must be able to sustain drives and burn clock against tough opponents or they will wear down your defense, this is where "all pass" teams run into problems)
I hope that this gives you some starting points for creating effective offenses. It doesn't really matter how many formations or playbooks that you have or use, it is all about giving your team a greater percentage of opportunities than you are going to allow your opponent to have. It doesn't mean that you are going to win every game that you have created such an advantage, because sometimes the dice just roll against you or your opponent is using 8 sided dice against your 6 sided dice (Better Players). All you can really do is increase your chances of winning a play, and the more plays that you win the higher the chance that you are going to win the game.