There was a recent discussion around this:
https://www.whatifsports.com/forums/Posts.aspx?topicID=531518&TopicsTimeframe=180&TopicsPage=0
I put in two test teams with identical rosters, pitching staffs, etc... the only difference between the two teams was the roles I assigned the pitchers. On team one, I assigned the pitchers being tested as RPs and on team two, I assigned them as SPs. In both cases, they and the other pitchers on the roster had the same advanced settings.
The pitchers chosen for this tests were chosen specifically for their high IP/G. I wanted to use high IP/G pitchers that could throw a significant amount of pitches, as if there was a cap on SPs being used as RPs, that should show clearer. I chose
1966 Juan Marichal who had an IP/G of 8.31
1972 Gaylord Perry who had an IP/G of 8.36
1975 Gaylord Perry who had an IP/G of 8.36
1975 Catfish Hunter who had an IP/G of 8.41
Each of them are good on in-game fatigue as starters for ~130 pitches. I put their PC to allow up to 140 pitches to capture as much of their IP/G allotment as possible.
Given their IP/G, we should expect them to hit 0% on the in-game fatigue around 130 pitches. If there was a PC limit for SPs used as RPs, then we'd see that 0% effect starting earlier.